Donin AS, Dent JE, Nightingale CM, et al. Widespread publicity has been given to a few studies suggesting a pro-oxidant effect of vitamin C (204, 205), but these studies turned out to be either flawed or of no physiological relevance. Tessier F, Moreaux V, Birlouez-Aragon I, Junes P, Mondon H. Decrease in vitamin C concentration in human lenses during cataract progression. Am J Clin Nutr. "Vitamin C" Vitamin C and Cancer - Dr. Linus Pauling - How To Live Longer and Feel Better - Vitamin C Dr. Linus Pauling and Dr. Abram HofferVitamin C, Vita. Stamp LK, Zhu X, Dalbeth N, Jordan S, Edwards NL, Taylor W. Serum urate as a soluble biomarker in chronic gout-evidence that serum urate fulfills the OMERACT validation criteria for soluble biomarkers. Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. Corvallis, Oregon 97331, phone: 541-737-5075 | fax: 541-737-5077 Balogun OO, da Silva Lopes K, Ota E, et al. 1999;10(4):840-845. (PubMed), 104. 2000;71(2):530-536. J Alzheimers Dis. Diabetol Metab Syndr. In a small (n=23), open-label trial, combined supplementation with vitamin C (1,000 mg/day) and vitamin E (400 IU/day) to AD patients taking a cholinesterase inhibitor significantly increased antioxidant levels and decreased lipoprotein oxidation in CSF after one year, but had no effect on the clinical course of AD compared to controls (104). Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. (PubMed), 151. Intravenous vitamin C and cancer: a systematic review. Unlike plants and most animals, humans have lost the ability to synthesize vitamin C endogenously and therefore have an essential dietary requirement for this vitamin (see The Recommended Dietary Allowance). Yet, most studies were small and of short duration and thus did not assess the consequence of long-term use of antioxidant vitamins on the risk of vascular complications in diabetic patients. Oregon State University, Updated in July 2018 by: J Pharm Biomed Anal. (PubMed), 114. Vitamin C | Linus Pauling Institute | Oregon State University / Vitamin C Available at: https://www.alz.org/alzheimers-dementia/facts-figures. (PubMed), 124. Intake of vitamins B6 and C and the risk of kidney stones in women. It is important for individuals with significantly elevated blood pressure not to rely on vitamin C supplementation alone to reduce their hypertension. (PubMed), 121. A 2013 systematic review identified 11 randomized controlled studies that evaluated the effect of vitamin C on asthma (eight trials) or exercise-induced bronchoconstriction (three trials) (180). Sodium ascorbate and calcium ascorbate are the most common forms, although a number of other mineral ascorbates are available. 2018;148(3):419-426. A history of scurvy and vitamin C. In: Packer L, Fuchs J, eds. 1998;36(3):143-147. Amelioration of persistent left ventricular function impairment through increased plasma ascorbate levels following myocardial infarction. Proc Natl Acad Sci U S A. Diabet Med. Int J Cancer. These products are all Lp (a) binding inhibitors. 2012;130(1):147-158. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. (PubMed), 30. Related to this oxidation -reduction ( redox) potential, two major functions of vitamin C are as an antioxidant and as an enzyme cofactor (1). A vitamin C intake of at least 400 mg daily may be particularly important for older adults who are at higher risk for age-related chronic diseases. Fructose and vitamin C intake do not influence risk for developing hypertension. 1998;147(12):1162-1174. Taylor EN, Stampfer MJ, Curhan GC. 1. In a cohort of 21,831 adults followed for 12 years in the EPIC-Norfolk study, high plasma vitamin C was found to be strongly associated with a reduced risk of diabetes(84). Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review. (PubMed), 165. 1999;281(15):1415-1423. This is typically observed at doses between 200 to 400 mg/day in healthy young adults, with some degree of individual variation (23, 24). He received these awards for chemistry in 1954 and for peace in 1962. . Int J Vitam Nutr Res. Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB. 2011;42(6):1665-1672. Vitamin C, through its antioxidant functions, has been shown to protect leukocytes from self-inflicted oxidative damage (14). However, leukocyte vitamin C concentration does not accurately reflect vitamin C in several tissues and may specifically underestimate vitamin C uptake into skeletal muscle (26). J Am Coll Nutr. (PubMed), 167. 2017;151(6):1229-1238. Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. (PubMed), 170. 2011;51(5):1068-1084. Accessed 6/22/18. Lysine also prevents collagen-digesting enzymes from destroying collagen. (PubMed), 192. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract. (PubMed), 18. Using this approach, Dr. Pauling suggested in the early 1970s that the optimum daily intake may be about 2,000 milligrams of vitamin C and that everyone should get at least 200 to 250 mg/day. 2004;80(6):1508-1520. Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. While plasma vitamin C concentration reflects recent dietary intake, leukocyte (white blood cell) vitamin C is thought to be an indicator of body stores. Am J Epidemiol. Limitations inherent to dietary assessment methodology, such as recall bias, measurement error, and residual confounding, may account for some of the inconsistent associations between vitamin C intake and CHD risk. Vitamin C also limited endothelial dysfunction that was experimentally induced in healthy volunteers (39). PDF The Cure for Heart Disease: Condensed - Cardiacos.net (PubMed), 150. Proc Natl Acad Sci U S A. Hypertension is a major risk factor for cardiovascular disease, including coronary heart disease, stroke, and atrial fibrillation. Vitamin C (L-ascorbic acid) is available in many forms, but there is little scientific evidence that any one form is better absorbed or more effective than another. 2001;108(3):E55. Over years of buildup and accumulated damage to the coronary arteries, CHD may culminate in a myocardial infarction or heart attack. The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. (PubMed), 43. A randomized, double-blind, placebo-controlled trial in more than 14,000 older men participating in the Physicians Health Study II (PHS II) found that vitamin C supplementation (500 mg/day) for an average of eight years had no significant effect on the incidence of or mortality from any type of stroke (53). Sauberlich HE. Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. The Pauling therapy is a combination of the specific orthomolecular nutrients - ascorbic acid, lysine and proline - that are proven to combat coronary heart disease at the specific dosages recommended by Linus Pauling. In the second prospective cohort study, the Diet, Cancer and Health Study, 55,543 Danish adults (ages 50-64 years) were questioned at baseline about their lifestyle, diet, and supplement use during the previous 12 months (125). Atherosclerosis. 25. 2005;4:5. Clin Neuropsychol. Reversal of ionoregulatory disruptions in occupational lead exposure by vitamin C. Environ Toxicol Pharmacol. Regarding the incidence of colds, a difference was observed between two groups of participants. Potentiation of in vitro and in vivo lymphocyte responses. 2016;5(2):94-100. Oregon State University, Updated in November 2013 by: Phagocytic leukocytes also produce and release cytokines, including interferons, which have antiviral activity (16). (PubMed), 153. While the Sesso study showed no mortality benefit, many previous studies such as the Enstrom Study showed a striking 40% reduction in all-cause mortality over 6 years from the same 500 mg daily vitamin C . Regular supplementation with vitamin C (0.25 to 2 g/day) did not reduce the incidence of colds in the general population (23 trials); however, in participants undergoing heavy physical stress (e.g., marathon runners, skiers, or soldiers in subarctic conditions), vitamin C supplementation halved the incidence of colds (5 trials). Banerjee S, Hawksby C, Miller S, Dahill S, Beattie AD, McColl KE. On the other hand, two other large prospective studies reported that a high intake of vitamin C was associated with an increased risk of kidney stone formation in men (198, 199). (PubMed). PDF Chapter 7 The Pauling Therapy - Practicing Medicine Without A License By the late 1700s, the British navy was aware that scurvy could be cured by eating oranges or lemons, even though vitamin C would not be isolated until the early 1930s. Linus Pauling's Recommendations for Vitamin C and Lysine - The Ezekiel Diet Files Linus Pauling's Recommendations for Vitamin C and Lysine by EzekielDiet.com Posted on Sep 22, 2021 Pauling's Vitamin C and Lysine dosage recommendations from his Unified Theory Lecture on Heart Disease. Although free metal ions are not generally found under physiological conditions, the idea that high doses of vitamin C might be able to promote oxidative damage in vivo has received a great deal of attention. (PubMed), 145. Depletion-repletion pharmacokinetic experiments demonstrated that plasma vitamin C concentration is tightly controlled by three primary mechanisms: intestinal absorption, tissue transport, and renal reabsorption (22). Production of both collagen and elastin requires vitamin C, lysine and proline. Harding AH, Wareham NJ, Bingham SA, et al. A 2015 meta-analysis of 29 randomized controlled trials found that administration of vitamin C during pregnancy, alone or in combination with a few other supplements, failed to reduce the risks of stillbirth, perinatal death, intrauterine growth restriction, preterm birth, premature rupture of membranes, and preeclampsia (88). Because oxalate is a metabolite of vitamin C, there is some concern that high vitamin C intake could increase the risk of calcium oxalate kidney stones. Cigarette smoking or second-hand exposure to cigarette smoke contributes to increased blood lead concentration and a state of chronic low-level lead exposure. Stamp LK, O'Donnell JL, Frampton C, Drake JM, Zhang M, Chapman PT. Additionally, work by Linus Pauling Institute investigators has shown that cellular uptake of vitamin C declines with age, supporting the notion that vitamin C requirements are increased in the elderly. 177. A small randomized controlled trial performed in 60 ischemic stroke patients showed that intravenous vitamin C administration (500 mg/day for 10 days, initiated day 1 post-stroke) had no effect on serum markers of oxidative stress or neurological outcomes compared to placebo(143). (PubMed), 122. http://practicingmedicinewithoutalicense.com/protocol/excerpt_chp7.pdf He received a patent on his work. Am J Clin Nutr.

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